MyOme ya gabatar da bayanai daga wani takarda a taron Ƙungiyar Jama'ar Dan Adam na Amirka (ASHG) wanda ya mayar da hankali kan hadedde haɗarin haɗarin polygenic (caIRS), wanda ya haɗu da kwayoyin halitta tare da abubuwan haɗari na asibiti na al'ada don inganta ganewar mutane masu haɗari ga cututtuka na jijiyoyin jini. (CAD) a cikin mutane daban-daban.
Sakamakon ya nuna cewa caIRS sun fi gano daidaikun mutane a cikin haɗarin haɓaka cututtukan jijiyoyin jini, musamman a tsakanin iyakokin iyaka ko matsakaicin nau'ikan haɗarin asibiti da kuma na mutanen Kudancin Asiya.
A al'adance, yawancin kayan aikin tantance haɗarin CAD da gwaje-gwaje an inganta su akan ƴan ƴan ƴan ɗimbin jama'a, a cewar Akash Kumar, MD, PhD, babban jami'in kula da lafiya da kimiyya na MyOme.Mafi yawan kayan aikin da ake amfani da su, Ciwon Ciwon Jiki na Atherosclerotic (ASCVD) Pooled Cohort Equation (PCE), ya dogara da daidaitattun matakan kamar matakan cholesterol da matsayin ciwon sukari don tsinkayar hadarin CAD na shekaru 10 da kuma yanke shawara game da farawa na maganin statin, in ji Kumar. .
Yana haɗa miliyoyin bambance-bambancen kwayoyin halitta
Ƙididdigar haɗarin polygenic (PRS), wanda ke tara miliyoyin bambance-bambancen kwayoyin halitta na ƙananan tasiri cikin maki ɗaya, yana ba da damar inganta daidaiton kayan aikin tantance haɗarin asibiti, "in ji Kumar.MyOme ya haɓaka kuma ya inganta ƙimar haɗari mai haɗaka wanda ya haɗa PRS na giciye tare da caIRS.
Mahimmin binciken da aka samu daga gabatarwar ya nuna cewa caIRS sun inganta nuna bambanci sosai idan aka kwatanta da PCE a cikin dukkanin ƙungiyoyin tabbatarwa da kakanni da aka gwada.Har ila yau, caIRS ta gano har zuwa ƙarin ƙarin shari'o'in 27 na CAD a cikin mutane 1,000 a cikin rukunin PCE na kan iyaka/tsakiya.Bugu da kari, mutanen Kudancin Asiya sun nuna mafi girman karuwar wariya.
"Makin haɗari na MyOme na iya haɓaka rigakafin cututtuka da gudanarwa a cikin kulawa ta farko ta hanyar gano mutane da ke cikin haɗarin haɓaka CAD, waɗanda watakila ba a rasa ba," in ji Kumar."Musamman, caIRS ya kasance mai tasiri sosai wajen gano mutanen Kudancin Asiya da ke cikin haɗari ga CAD, wanda ke da mahimmanci saboda yawan mace-macen CAD kusan ninki biyu idan aka kwatanta da na Turai."
Gabatarwar ta Myome ta kasance mai taken "Haɗuwa da Rikicin Haɗarin Polygenic tare da Abubuwan Kula da Lafiya suna Inganta Hasashen Hatsarin Ciwon Ciwon Jiji na Shekaru 10."
Lokacin aikawa: Nuwamba-10-2023