Masu nazarin abubuwan ci gaban da aka samu Platelet SEB-C100
Gabatarwar samfur
Platelet Derived Growth Factor Analyzer kayan aiki ne na gwaji da nazarci bisa tsarin gwaji na musamman wanda kamfaninmu ya yi.Mai tantancewa yana gano abubuwan haɓakar platelet, takamaiman alamar furotin a cikin fitsarin ɗan adam wanda aka samar lokacin da jijiyoyin jijiyoyin jini ya faru.Ana iya kammala binciken a cikin 'yan mintoci kaɗan ta amfani da 1ml na fitsari kawai.Mai tantancewa zai iya tantance ko jijiyoyin jijiyoyin jini suna da ƙwanƙwasa da kuma matakin stenosis don ba da tunani don ƙarin bincike.Hanyar ganowa da kuma hanyar bincike na mai nazarin abubuwan haɓakar haɓakar platelet shine hanyar gano asali na asali ba tare da ɓarna ba, wanda baya buƙatar allurai da magungunan taimako, kawar da matsalar da mutanen da ke fama da rashin lafiyar abubuwan da ke ɗauke da iodine ba su iya jurewa CT da sauran cututtukan zuciya. artery angiography.Mai nazari yana da fa'idodin ƙarancin farashi na gwaji, aikace-aikacen fa'ida, aikace-aikace mai sauƙi, saurin gwajin sauri, da sauransu, kuma sabon nau'in cututtukan jijiyoyin jini ne na ganowa da wuri da kayan aikin tantancewa.
Mai nazari yana da fa'idodi masu zuwa:
1. Sauri: Saka fitsari a cikin na'urar ganowa kuma jira 'yan mintuna kaɗan
2. Sauƙi: Gwaji ba kawai ana samunsa a asibitoci ba.Hakanan ana iya yin su a wuraren duba lafiyar likita, gidajen kulawa ko gidajen jin daɗin jama'a
3. Ta'aziyya: Ana buƙatar 1ml na fitsari kawai a matsayin samfur, babu jini, babu magani, babu allurai, babu damuwa game da rashin lafiyar jiki.
4. Hankali: Cikakken dubawa ta atomatik, aiki akan ba tare da kulawa ba
5. Sauƙaƙewa mai sauƙi: Ƙananan girman, za'a iya shigar da amfani da rabin tebur
6. Sauƙaƙe mai sauƙi: Saka idanu ta atomatik da kuma nuna matsayi mai amfani don sauƙin sauyawa mai amfani
Ka'idar samfurin
Raman spectroscopy yana amfani da watsewar haske don nazarin tsarin ƙwayoyin cuta da sauri.Wannan dabarar ta dogara ne akan ka'idar cewa lokacin da haske ya haskaka kwayar halitta, karo na roba yana faruwa kuma wani yanki na hasken ya watse.Mitar hasken da ke tarwatsewa ya bambanta da yawan hasken abin da ya faru, wanda aka sani da watsawar Raman.Ƙarfin watsawar Raman yana da alaƙa da tsarin kwayoyin halitta, yana ba da damar yin nazarin duka ƙarfinsa da mitarsa don tantance yanayin kwayoyin halitta da tsarin daidai.
Saboda raunin siginar Raman da tsangwama akai-akai, samun siginar Raman yayin gano ainihin na iya zama ƙalubale.Gano ingantaccen siginar Raman yana da wahala da gaske.Saboda haka, ingantaccen yanayin Raman spectroscopy na iya haɓaka ƙarfin hasken Raman da ke tarwatsewa sosai, yana magance waɗannan batutuwa.Ƙa'idar dabarar ta ƙunshi sanya abin da za a gano a kan wani ƙarfe na musamman, kamar azurfa ko zinariya.ta yadda za a haifar da m, nanometer-matakin saman, haifar da wani sakamako na inganta surface.
An nuna cewa bakan Raman na ma'aunin haɓakar haɓakar platelet (PDGF-BB) ya nuna wani kololuwa na musamman a 1509 cm-1.Bugu da ari, an tabbatar da cewa kasancewar alamar haɓakar haɓakar haɓakar platelet (PDGF-BB) a cikin fitsari yana da alaƙa da jijiyoyin jijiyoyin jini.
Ta Amfani da Raman spectroscopy da fasaha na haɓaka ƙasa, mai nazarin PDGF zai iya auna gaban PDGF-BB da halayen kololuwar 'ƙarfin fitsari.Wannan yana ba da damar tantance ko arteries na jijiyoyin jini suna stenotic da matakin stenosis, don haka samar da tushe don ganewar asibiti.
Bayanan samfurin
A cikin 'yan shekarun nan, yaduwar cututtukan zuciya na zuciya yana ƙaruwa sannu a hankali saboda sauyin yanayin abinci da salon rayuwa, da kuma yawan tsufa.Adadin mace-macen da ke hade da cututtukan zuciya ya kasance mai girma da ban tsoro.Rahoton kiwon lafiya da cututtukan zuciya na kasar Sin na shekarar 2022 ya nuna cewa, yawan mace-macen cututtukan zuciya a cikin biranen kasar Sin zai kai 126.91/100,000 da 135.88/100,000 a tsakanin mazauna karkara a shekarar 2020. Alkaluman yana karuwa tun daga shekarar 2012 tare da karuwa sosai. a yankunan karkara.A cikin 2016, ya zarce na matakin birni kuma ya ci gaba da haɓakawa a cikin 2020. A halin yanzu, arteriography na jijiyoyin jini shine hanyar gano asali na farko da aka yi amfani da shi a cikin saitunan asibiti don gano cututtukan cututtukan zuciya.Yayin da ake magana da shi a matsayin "ma'auni na zinariya" don ganewar cututtukan zuciya na zuciya, cin zarafi da tsadarsa sun haifar da haɓakar bugun jini na electrocardiography a matsayin hanyar da za a iya ganowa a hankali.Ko da yake ganewar electrocardiogram (ECG) abu ne mai sauƙi, dacewa, kuma maras tsada, kuskuren ganewar asali da kuma watsi da cututtuka na iya faruwa har yanzu, yana mai da shi rashin dogara ga ganewar asibiti na cututtukan zuciya.Sabili da haka, haɓaka hanyar da ba ta da haɗari, mai mahimmanci, kuma abin dogara don ganowa da wuri da sauri na cututtukan zuciya na zuciya yana da mahimmanci.
Raman spectroscopy mai haɓakawa (SERS) ya sami aikace-aikacen tartsatsi a cikin ilimin kimiyyar rayuwa don gano ƙwayoyin halittu a cikin ƙananan ƙima.Alal misali, Alula et al.sun sami damar gano matakan creatinine na mintuna kaɗan a cikin fitsari ta amfani da SERS spectroscopy tare da gyare-gyaren hoto na nanoparticles na azurfa da ke ɗauke da sinadarai na maganadisu.
Hakanan, Ma et al.An yi amfani da tarawar nanoparticles a cikin SERS spectroscopy don bayyana ƙarancin adadin deoxyribonucleic acid (DNA) a cikin ƙwayoyin cuta.
Platelet-derived growth factor-BB (PDGF-BB) yana taka muhimmiyar rawa a ci gaban atherosclerosis ta hanyoyi da yawa kuma yana da kusanci da cututtukan zuciya.Enzyme-linked immunosorbent assay (ELISA) ita ce babbar hanyar da ake amfani da ita a cikin binciken PDGF-BB na yanzu don gano wannan furotin a cikin jini.Alal misali, Yuran Zeng da abokan aiki sun ƙaddara ƙwayar plasma na PDGF-BB ta hanyar amfani da enzyme-linked immunosorbent assay kuma sun gane cewa PDGF-BB yana ba da gudummawa sosai ga pathogenesis na carotid atherosclerosis.A cikin bincikenmu, mun fara bincikar sifofin SERS na hanyoyin magance ruwa na PDGF-BB daban-daban tare da ƙarancin ƙima, ta amfani da dandamalinmu na 785 nm Raman spectroscopy.Mun gano cewa halayen kololuwa tare da canjin Raman na 1509 cm-1 an sanya su zuwa maganin ruwa na PPGF-BB.Bugu da ƙari, mun gano cewa waɗannan halayen kololuwa kuma suna da alaƙa da maganin ruwa na PDGF-BB.
Kamfaninmu ya haɗu tare da ƙungiyoyin bincike na jami'a don gudanar da bincike na SERS akan jimillar samfuran fitsari 78.Waɗannan sun haɗa da samfuran 20 daga marasa lafiya waɗanda aka yi wa tiyata na PCI, samfuran 40 daga marasa lafiya waɗanda ba su yi aikin PCI ba, da samfuran 18 daga mutane masu lafiya.Mun yi nazari sosai kan sigar fitsarin SERS ta hanyar haɗa kololuwar Raman tare da mitar Raman na 1509cm-1, wanda ke da alaƙa kai tsaye zuwa PDGF-BB.Binciken ya nuna cewa samfuran fitsari na marasa lafiya waɗanda aka yi wa tiyata na PCI suna da ƙimar ƙima na 1509cm-1, yayin da wannan kololuwar ba ta nan a cikin samfuran fitsari na mutane masu lafiya da mafi yawan marasa lafiya na PCI.A lokaci guda, lokacin da aka haɗu da bayanan asibiti na asibiti na cututtukan zuciya na angiography, an ƙaddara cewa wannan hanyar ganowa ta yi daidai da ƙayyadaddun idan akwai toshewar zuciya da jijiyoyin jini fiye da 70%.Haka kuma, wannan hanya za a iya gano tare da ji na ƙwarai da kuma takamaiman 85% da kuma 87% bi da bi, da mataki na blockage fiye da 70% a lokuta da cututtukan zuciya da jijiyoyin jini cututtuka ta hanyar gano kololuwa na Raman na 1509 cm-1.5%, sabili da haka, ana tsammanin wannan hanyar za ta zama muhimmin tushe don yanke shawara idan marasa lafiya da ke fama da cututtukan jijiyoyin jini suna buƙatar PCI, suna ba da fa'idodi masu fa'ida sosai don gano farkon abubuwan da ake zargi da kamuwa da cututtukan jijiyoyin jini.
Idan aka ba da wannan bayanan, kamfaninmu ya aiwatar da sakamakon bincikenmu na farko ta hanyar ƙaddamar da Platelet Derived Growth Factor Analyzer.Wannan na'urar za ta canza mahimmancin haɓakawa da amfani da yawa don gano cututtukan zuciya na farko.Za ta ba da gudummawa sosai wajen inganta lafiyar zuciya a kasar Sin da ma duniya baki daya.
Littafi Mai Tsarki
[1] Huinan Yang, Chengxing Shen, Xiaoshu Cai et al.Binciken da ba a taɓa gani ba kuma mai yiwuwa na cututtukan zuciya na jijiyoyin jini tare da fitsari ta amfani da ingantaccen yanayin Raman spectroscopy [J].Manazarta, 2018, 143, 2235-2242.
Sigar zanen gado
| lambar samfurin | Saukewa: SEB-C100 |
| abun gwaji | Ƙarfin haɓakar abubuwan haɓakar platelet ya haifar da kololuwar fitsari |
| Hanyoyin Gwaji | sarrafa kansa |
| Harshe | Sinanci |
| Ƙa'idar Ganewa | Raman spectroscopy |
| sadarwar sadarwa | Micro USB Port, Network Port, WiFi |
| maimaituwa | Adadin bambancin sakamakon gwaji ≤ 1.0% |
| matakin daidaito | Sakamako suna daidaitawa tare da ƙimar samfurin ma'auni masu dacewa. |
| kwanciyar hankali | Coefficient na bambancin ≤1.0% don samfurin iri ɗaya a cikin sa'o'i 8 na wutar lantarki |
| Hanyar yin rikodi | LCD nuni, FlashROM ajiya bayanai |
| lokacin ganowa | Lokacin gano samfur guda ɗaya bai wuce daƙiƙa 120 ba |
| Ƙarfin Aiki | Adaftar wutar lantarki: AC 100V ~ 240V, 50/60Hz |
| girma na waje | 700mm (L)*560mm(W)*400mm(H) |
| nauyi | Kimanin 75kg |
| yanayin aiki | zafin aiki: 10 ℃～ 30 ℃;dangi zafi: ≤90%;karfin iska: 86kPa ~ 106kPa |
| Harkokin sufuri da yanayin ajiya | zafin aiki: -40 ℃～55 ℃;dangi zafi: ≤95%;karfin iska: 86kPa ~ 106kPa |
